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专利名称：Dimethylbenzofuran and
dimethylbenzopyran derivatives and theiruse as 5- HT3 antagonists
发明人：Georges Henri Paul Van Daele,Jean-Paul
Rene Marie Andre Bosmans,Willy JoannesCarolus Van Laerhoven
申请号：US08/416914申请日：19950616公开号：US05674868A公开日：19971007
摘要：Method of treating 5-HT.sub.3 -mediated disorders, which comprises systemicadministration of an effective amount of a compound of formula (I) ##STR1## thepharmaceutically acceptable acid addition salt forms and the stereochemically isomericforms thereof, wherein R.sup.1 and R.sup.2 represent hydrogen, or R.sup.1 and R.sup.2taken together form a bivalent radical of formula --CH═CH--CH═CH-- (a), -- CH═C(Cl)--CH═ CH-- (b) or --CH═CH--C(Cl)═CH-- (c); n represents 2, 3 or 4; R. sup.3 representshydrogen or methoxy; m represents 1 or 2; R.sup.4 represents hydrogen, amino orC.sub.1-3 - alkylcarbonylamino; and R.sup.5 represents hydrogen or halo; novel
compounds; compositions; processes for preparing novel compounds and intermediates.
申请人：JANSSEN PHARMACEUTICA N.V.
代理人：Charles J. Metz
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