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专利名称：Nitrosated and nitrosylated compounds and
compositions and their use for treatingrespiratory disorders
发明人：David S. Garvey,L. Gordon Letts,H. Burt
Renfroe,Stewart K. Richardson
申请号：US104236申请日：20030505
公开号：US20030199529A1公开日：20031023
摘要：Disclosed are (i) compounds of a steroid, a &bgr;-agonist, an anticholinergic, amast cell stabilizer and a phosphodiesterase (PDE) inhibitor directly or indirectly linkedto a NO or NOgroup or a group which stimulates endogenous production of NO or EDRFin vivo; (ii) compositions of steroids, &bgr;-agonists, anticholinergics, mast cell stabilizersand PDE inhibitors, which can optionally be substituted with at least one NO or NOmoietyor a group which stimulates endogenous production of NO or EDRF in vivo, and acompound that donates, transfers or releases nitric oxide as a charged species, i.e.,nitrosonium (NO) or nitroxyl (NO), or as the neutral species, nitric oxide (NO•) or thatstimulates endogenous production of NO or EDRF in vivo; and (iii) uses for them inpreventing and/or treating respiratory disorders.
申请人：GARVEY DAVID S.,LETTS L. GORDON,RENFROE H. BURT,RICHARDSONSTEWART K.
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